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Partnerships

A strong network of partners is crucial for our goal to provide the next generation of active implants. In neurotechnology or in the development of systems for other applications – we are constantlyworking on the improvement of our products and technology. 

Therefore, it is of most importance to us to work together with partners worldwide in projects and always listen to the feedback of our customers.

Let us know if you are working on a project and are in need of a strong partner on the technology side. We are happy to gain you as a new partner for the use of our active implant technologies.

Reference Customers

Leading investigators and companies around the world rely on our products which we produce according to highest quality standards. Therefore, we are very happy to support top-level research as well as the development of highly efficient new therapies.

Papers & Publications Involving CorTec Products

Our products are involved in research and development projects worldwide. Following a list of papers published by our customers*.
Follow the links to read the full papers.

More literature on our products as well as on several applications you can find here.

*If you know of a paper that is not listed here we are happy to receive this information at info@cortec-neuro.com

Human-relevant near-organ neuromodulation of the immune system via the splenic nerve.

Donegá, Matteo, et al.; PNAS 118.20 (2021).

Stretchable, Fully Polymeric Electrode Arrays for Peripheral Nerve Stimulation.

Cuttaz, Estelle A., et al.; Advanced Science (2021): 2004033.

A Software Tool for the Real-Time in Vivo Evaluation of Neural Electrodes’ Selectivity.

Strauss, Ivo, et al.; 10th International IEEE/EMBS Conference on Neural Engineering (NER) (2021).

Restoring tactile sensation using a triboelectric nanogenerator.

Shlomy, Iftach, et al.; ACS Nano (2021).

In-vivo application of low frequency alternating currents on porcine cervical vagus nerve evokes reversible nerve conduction block.

Muzquiz, Maria I., et al.; Bioelectronic Medicine 7.9 (2021).

Implanted Nerve Electrical Stimulation allows to Selectively Restore Hand and Forearm Movements in Patients with a Complete Tetraplegia.

Tigra, Wafa, et al.; Journal of NeuroEngineering and Rehabilitation volume 17, Article number: 66 (2020).

Sensory pudendal nerve stimulation increases bladder capacity through sympathetic mechanisms in cyclophosphamide‐induced cystitis rats.

Gonzalez, Gril; Neurourology and Urodynamics 38.1 (2019): 135-143.

Optogenetic activation of fiber-specific compound action potentials in the mouse vagus nerve.

Téa Tsaava, Adam M. Kressel et al.; 9th International IEEE EMBS Conference on Neural Engineering, San Francisco, CA, USA, March 20 – 23 , 2019
 

Optimization of the electrode drive pattern for imaging fascicular compound action potentials in peripheral nerve with fast neural electrical impedance tomography (EIT).

Enrico Ravagli et al.; Physiological Measurement 2019.

Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig.

Cathrine T. Fjordbakk et al.; Scientific Reports 9, 18136 (2019).

An impedance matching algorithm for common-mode interference removal in vagus nerve recordings.

Todd J. Levy et al.; Journal of Neuroscience Methods, 330, 2019.

Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes.

Mélanie Guyot et al.; Nature Biotechnology 2019.

Exploring selective neural electrical stimulation for upper limb functions restoration.

W. Tigra, David Guiraud, David Andreu, Bertrand Coulet, Anthony Gelis, Charles Fattal, Pawel Maciejasz, Chloé Picq, Olivier Rossel, Jacques Teissier, Christine Azevedo Coste; European Journalf of Translational Myology 2016 26(2), 161-164.

Apical splenic nerve electrical stimulation discloses an anti-inflammatory pathway relying on adrenergic and nicotinic receptors in myeloid cells.

Guyot, Mélanie et al.; Brain, Behaviour, and Immunity 8 (2019) 238-246.

Identification of hypoglycemia-specific neural signals by decoding murine vagus nerve activity.

Masi, Emiliy Battinelli et al.; Bioelectronic Medicine (2019) 5:9.

Miniature electroparticle-cuff for wireless peripheral neuromodulation.

Hernandez-Reynoso, Ana G. et al.; J. Neural Eng. 2019 16 046002.

A neural circuit for gut-induced reward.

Han, Wenfei, et al.; Cell 175.3 (2018): 665-678.

A wrappable microwire electrode for awake, chronic interfacing with small diameter autonomic peripheral nerves.

Falcone, Jessica D., et al.; bioRxiv(2018): 402925.

Classification of naturally evoked compound action potentials in peripheral nerve spatiotemporal recordings.

Koh, Ryan GL, Adrian I. Nachman, and Jose Zariffa.; bioRxiv(2018): 469874.

Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity.

Zanos, Theodorsos P., et al; PNAS, vol. 115, no. 21, E4851 (2018).

Standardization of methods to record Vagus nerve activity in mice.

Silverman, Harold A., et al.; Bioelectronic Medicine 4.1 (2018): 3.

A Multi-Sensor and Parallel Processing SoC for Miniaturized Medical Instrumentation

Schoenle, P., et al.; in IEEE Journal of Solid-State Circuits, vol. 53, no. 7, pp. 2076-2087, July 2018.

Stimulation of the sensory pudendal nerve increases bladder capacity in the rat. 

Hokanson, James A., et al.; American Journal of Physiology-Renal Physiology 314.4 (2017): F543-F550.

Chronic cuffing of cervical vagus nerve inhibits efferent fiber integrity in rat model.

Somann, Jesse Paul, et al;  Journal of neural engineering (2017).

A multi-sensor and parallel processing SoC for wearable and implantable telemetry systems.

Schoenle, P., et al.; ESSCIRC 2017-43rd IEEE European Solid State Circuits Conference. IEEE, 2017.

Modulation of Calcitonin, Parathyroid Hormone, and Thyroid Hormone Secretion by Electrical Stimulation of Sympathetic and Parasympathetic Nerves in Anesthetized Rats.

Hotta, Harumi, et al.; Frontiers in neuroscience 11 (2017): 375.

The effects of neuromodulation in a novel obese-prone rat model of detrusor underactivity.

Gonzalez, Eric J., and Warren M. Grill; American Journal of Physiology-Renal Physiology (2017): F815-F825.

Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes.

Sacramento, Joana F., et al.; Diabetologia (2017): 1-11.

High-frequency electrical modulation of the superior ovarian nerve as a treatment of polycystic ovary syndrome in the rat.

Pikov, Victor X., Arun Sridhar, and Hernan E. Dr Lara; Frontiers in Physiology 9 (2018): 459.

Stimulation of the Pelvic Nerve Increases Bladder Capacity in the Prostaglandin E2 Rat Model of Overactive Bladder.

Langdale, Christopher L., et al.; American Journal of Physiology-Renal Physiology (2017): ajprenal-00116.

Spatial and activity-dependent catecholamine release in rat adrenal medulla under native neuronal stimulation.

Kyle Wolf, Georgy Zarkua, Shyue‐An Chan, Arun Sridhar, Corey Smith; Physiological Reports Vol. 4, Iss. 27 (2016 ), 1-13.

Phasic activation of the external urethral sphincter increases voiding efficiency in the rat and the cat.

Christopher L. Langsdale, Warren M. Grill; Experimental Neurology 285 (Pt B) 2016 Nov, 173-181.

Cytokine-specific Neurograms In the Sensory Nerve.

Benjamin E. Steinberg, Harold A Silverman, Sergio Robbiati, Manoj K Gunasekaran, Téa Tsaava, Emily Battinelli, Andrew Stiegler, Chad E Bouton, Sangeeta S Chavan, Kevin J Tracey, Patricio T Huerta ; Bioelectronic Medicine 2016, 7-17.

Conductive hydrogel electrodes for delivery of long-term high frequency pulses.

Staples, Naomi A., et al.; Frontiers in Neuroscience 11 (2017): 748.

A micro-scale printable nanoclip for electrical stimulation and recording in small nerves.

Lissandrello, C. A., et al.; Journal of neural engineering 14.3 (2017): 036006.

Unsupervised machine learning can delineate central sulcus by using the spatiotemporal characteristic of somatosensory evoked potentials.

Asman, Priscella, et al.; Journal of Neural Engineering 18.4 (2021)

Epidural and transcutaneous spinal cord stimulation facilitates descending inputs to upper-limb motoneurons in monkeys.

Guiho, Thomas, et al.; Journal of Neural Engineering 18.4 (2021)

Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable.

John, Sam E. et al.; Scientific Reports (2018) 8:8427.

A novel neural prosthesis providing long-term electrocorticography recording and cortical stimulation for epilepsy and brain-computer interface.

Romanelli, Pantaleo et al.; J Neurosurg May 11, 2018.

In vivo impedance characterization of cortical recording electrodes shows dependence on electrode location and size.

John SE, et al.; IEEE Trans Biomed Eng. 2018 Jul 10.

Characterization of Hand Clenching in Human Sensorimotor Cortex Using High-, and Ultra-High Frequency Band Modulations of Electrocorticogram.

Jiang, Tianxiao, et al.; Frontiers in Neuroscience 12 (2018): 110.

Mapping the fine structure of cortical activity with different micro ECoG electrode array geometries.

Xi Wang et al 2017; J. Neural Eng. 14 056004.

Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity.

Thomas J Oxley,  Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Tracey L Wheeler, Jack W Judy et al.; Nature Biology 34 (2016), 320–327.

In vitro assessment of long-term reliability of low-cost μΕCoG arrays.

Palopoli-Trojani, Kay, et al.; Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference of the IEEE, 2016.

A critical review of cell culture strategies for modelling intracortical brain implant material reactions.

Gilmour, Aaron D., et al.; Biomaterials 91 (2016): 23-43.

Partners in Research & Development

Albert-Ludwigs-Universität Freiburg
(University of Freiburg)

Department of Microsystems Engineering (IMTEK) /
Laboratory for Biomedical Microtechnology

Prof. Dr. Thomas Stieglitz

In collaboration with Prof. Dr. Thomas Stieglitz and his team, CorTec has developed the proprietary °AirRay electrode technology. His department also supports further development of various aspects of the CorTec Brain Interchange implant system. Professor Stieglitz’s laboratory is certified according to DIN EN ISO 13485 (standard for medical devices) for the development and production of neurotechnological implants.

www.imtek.de/bmt

Imtek, CorTec, Forschung, Research, Partner

Bernstein Zentrum Freiburg

Prof. Dr. Ad Aertsen

Prof. Dr. Ad Aertsen, professor for neurobiology and biophysics at the Faculty of Biology of the University of Freiburg, is an internationally renowned brain researcher and co-founder of the Bernstein Center Freiburg. The research conducted by his work groups has resulted in the initial idea of developing a product based on the brain-machine-interface (BMI) technology.

With the Bernstein Center for Computational Neuroscience (BCCN) and the Bernstein Focus: Neurotechnology (BFNT), the Bernstein Center bundles research units that investigate and decode brain functions. Their findings are also contributing to CorTec’s developmental work.

www.bcf.uni-freiburg.de

www.brainworks.uni-freiburg.de

BCF, CorTec, Forschung, Research, Partner

University Medical Center Freiburg

Neurology / Epilepsy Center

Prof. Dr. Andreas Schulze-Bonhage, Dr. Tonio Ball

Under the direction of Prof. Dr. Andreas Schulze-Bonhage, the Epilepsy Center focuses on diagnostics and therapy of epilepsy patients. In case surgical treatment is necessary, some of the patients need to have electrodes implanted for precise diagnosis. These patients represent the only medically motivated case in which brain activity can be recorded directly from the human brain over a longer period of time.

Dr. Tonio Ball directs a research group that functionally analyzes the brain with the help of these patients (among other subjects) in order to use the results for brain-machine-interface (BMI) technologies such as those developed by CorTec.

www.uniklinik-freiburg.de/epilepsy

www.ieeg.uni-freiburg.de

Neurosurgery

Prof. Dr. Volker Coenen, OA Dr. Peter Reinacher, OA Dr. Mortimer Gierthmühlen

The Department of Neurosurgery is an important partner of the Epilepsy Center. All surgical procedures with the Center’s patients are performed here. In addition, Prof. Coenen’s Department for Stereotactic Neurosurgery collaborates with CorTec towards clinical studies using the CorTec Brain Interchange system.

www.uniklinik-freiburg.de/neurosurgery

Universitätsklinikum Freiburg, CorTec, Forschung, Research, Partner

University Medical Center Tübingen

Institute of Medical Psychology and Behavioral Neurobiology

Prof. Dr. Niels Birbaumer, Dr. Ander Ramos Murguialday

Prof. Dr. Niels Birbaumer is an internationally renowned pioneer in the field of BMI. For instance, his group investigates ways in which severely paralyzed patients – up to the complete locked-in state – can communicate with the outside world again. Searching for improved methods for rehabilitation after a stroke is also part of his research. His findings provide CorTec’s work with key insights.

www.medizin.uni-tuebingen.de/Research/Institutes/MedicalPsychology

Neurology

Prof. Dr. Ulf Ziemann

Prof. Dr. Ulf Ziemann is an important clinical partner in the exploration of vascular neurological diseases. He is the medical director of the Department of Neurology with a focus on vascular neurology at the University Medical Center Tübingen. In addition, he heads the related research department at Hertie Institute for clinical brain research in Tübingen.

www.medizin.uni-tuebingen.de/de/das-klinikum/einrichtungen/kliniken/neurologie

Neurosurgery

Prof. Dr. Alireza Gharabaghi

Prof. Dr. Alireza Gharabaghi contributes a neurosurgeon’s perspective on new possibilities for stroke rehabilitation.

www.neurochirurgie-tuebingen.de

Universitätsklinik Tübingen, CorTec, Forschung, Research, Partner

University of Ulm

Institute of Microelectronics

Prof. Dr. Maurits Ortmanns

Research at Prof. Dr. Maurits Ortmanns’ institute is focused on circuits and electronics for biomedical applications. He supports CorTec in the development of the implant electronics, especially with a custom-designed microchip that is tuned exactly to the application in the Brain Interchange implant system.

www.uni-ulm.de/en/in/institute-of-microelectronics.html

Universität Ulm, CorTec, Forschung, Research, Partner

University of Houston

Department of Biomedical Engineering

Prof. Dr. Nuri Firat Ince

The research in Dr. Ince’s clinical neural engineering laboratory works on invasive brain machine interfaces and neuromarkers that could improve deep brain stimulation for the therapy of Parkinson’s disease. In addition, his team is currently investigating the application of state-of-the-art neural decoding algorithms with high density electrodes for the improvement of brain surgery in glioma and epilepsy. He cooperates with CorTec as a beta user for innovative research electrodes.

www.bme.uh.edu/research/ince_research_lab

University of Houston, CorTec, Forschung, Research, Partner

Multi Channel Systems GmbH (MCS)

The company, located in Reutlingen, specializes in the development and production of instruments for finest measurements of electrochemical signal transmissions in the nervous system, as they are employed in electrophysiology. The first versions of the CorTec Brain Interchange implant electronics were developed in collaboration with MCS.

www.multichannelsystems.com

Multichannel Systems, CorTec, Forschung, Research, Partner